Calcitriol Anti-T2DM Gene Targets in MIN6 Cells

Potential key target genes STAT3, HSP90AA1, MAPK1, and PIK3R1 identified via network pharmacology and molecular docking for calcitriol's effect on Type 2 Diabetes. The dataset likely contains mRNA and protein expression levels validated in a high glucose-induced MIN6 pancreatic β-cell model. Fanqiang Zeng published the data on figshare in April 2026.

Use Cases

• Validate computational predictions of drug targets based on identified genes STAT3, HSP90AA1, MAPK1, and PIK3R1.
• Analyze gene expression changes in pancreatic β-cells under high glucose conditions.
• Study the relationship between endoplasmic reticulum stress and Type 2 Diabetes progression.
• Correlate mRNA and protein level data for potential therapeutic targets.
• Benchmark network pharmacology results against experimental cell model data.

Strengths

• Data is derived from an integrated approach combining network pharmacology, molecular docking, and experimental validation.
• Specific genes STAT3, HSP90AA1, MAPK1, and PIK3R1 are identified as key targets.
• Functional assessments include CCK-8 assays and flow cytometry for cell survival and death.
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is 15.7 KB, indicating a very limited scope.

Provenance

Source

figshare

Collection Method

Integrated network pharmacology, molecular docking, and validation using a high glucose-induced MIN6 cell model.

Freshness

Last updated 2026-04-16 17:32:13; freshness should be verified.