Prototheca Infection Rates in Mice by Species, Dose, and Immune Status

A murine model study of protothecosis infection by Angelika Proskurnicka, last updated in 2026. It includes data from 324 mice across 54 experimental groups, infected with three pathogenic and one saprophytic Prototheca species. The dataset records infection rates, cytokine profiles, and the effects of inoculum size, infection route, and host immune status.

Use Cases

• Compare virulence between Prototheca species based on reported infection rates (P. ciferrii 61.1%, P. bovis 45.8%, P. wickerhamii 31.9%, P. stagnora 11.1%).
• Analyze the impact of host immune status on infection susceptibility based on the comparison between athymic (45.1%) and wild-type (29.9%) mice.
• Investigate the relationship between inoculum dose and infection yield based on the use of 10^6 and 10^7 colony-forming units.
• Study cytokine response patterns in protothecosis based on reported elevations in IL-10 and TNF-α levels.

Strengths

• Structured experimental design with 324 animals across 54 groups.
• Compares four Prototheca species and two mouse genotypes (immunocompetent and athymic).
• Reports specific quantitative outcomes, including infection rates for each species and cytokine levels.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 9.5 KB file size indicates a very small dataset with limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from a controlled murine model study.

Freshness

Last updated 2026-05-11 17:45:22; freshness should be verified.