Proteomic Pathway Enrichment for PFAS-Exposed Liver Cells

Canonical pathways with predicted enrichment scores following exposure to PFAS-treated extracellular vesicles. The dataset lists top pathways with -log p-values and associated differentially expressed proteins, authored by Celeste K. Carberry and last updated in March 2026. It is a small dataset, 9.5 KB in size, stored in an XLS file.

Use Cases

• Identify key biological pathways disrupted by PFAS exposure based on predicted enrichment scores.
• Analyze the relationship between differentially expressed proteins and specific canonical pathways.
• Validate in vitro findings on PFAS-induced liver toxicity using proteomic pathway analysis.

Strengths

• Data is licensed under CC-BY-4.0, allowing for open sharing and reuse.
• Includes specific -log p-values for pathway enrichment, providing a quantitative measure of significance.
• Focuses on a specific toxicological context: PFAS mixture effects on HepG2 liver cells.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is very small at 9.5 KB, indicating limited scope.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Celeste K. Carberry.

Collection Method

Likely derived from proteomic analysis of treated HepG2 cells.

Freshness

Last updated 2026-03-18 17:35:47