Cellular Component of Core Target Genes for Type 2 Diabetes

An 11.8 KB Excel file uploaded to figshare by Fanqiang Zeng on April 16, 2026. It contains data from a study investigating the therapeutic targets and mechanisms of calcitriol against Type 2 Diabetes Mellitus via endoplasmic reticulum stress-related pathways.

Use Cases

• Validate computational predictions of key targets like STAT3, HSP90AA1, MAPK1, and PIK3R1 based on network pharmacology analysis.
• Analyze mRNA and protein level changes in MIN6 cells under high glucose conditions based on PCR and western blot results.
• Model the relationship between calcitriol treatment and pancreatic β-cell survival based on CCK-8 assay and flow cytometry data.
• Investigate the role of endoplasmic reticulum stress pathways in Type 2 Diabetes progression based on the study's mechanistic focus.

Strengths

• Data is derived from an integrated approach combining network pharmacology, molecular docking, and experimental validation.
• Specific key targets (STAT3, HSP90AA1, MAPK1, PIK3R1) are identified and validated.
• File size is 11.8 KB, indicating a focused and manageable dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific experimental bias inherent to the MIN6 cell model study.

Provenance

Source

Fanqiang Zeng via figshare

Collection Method

Integrated approach combining network pharmacology, molecular docking, and experimental validation using a high glucose-induced MIN6 cell model.

Freshness

Last updated 2026-04-16 17:32:14; freshness should be verified.