OspA Monoclonal Antibody Characteristics for Lyme Disease Vaccine Research

A 5.5 KB dataset published on figshare by Graham G. Willsey, last updated on 2026-04-21. It contains characteristics of monoclonal antibodies (mAbs) targeting Outer surface protein A (OspA) of Borrelia burgdorferi, used in a study evaluating cross-serotype functionality. The data likely supports structural analysis for the design of a broadly protective Lyme disease vaccine.

Use Cases

• Classifying monoclonal antibody activity based on complement-dependent borreliacidal activity against seven OspA serotypes.
• Analyzing epitope conservation for vaccine design based on structural analysis of Fabs in complex with OspA.
• Identifying genetic determinants of susceptibility, such as Lys-107, across Borrelia burgdorferi genospecies.

Strengths

• Data is associated with a specific, peer-reviewed study methodology involving isogenic B. burgdorferi reporter strains.
• The dataset is small (5.5 KB), facilitating quick download and initial inspection.
• It is shared under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 5.5 KB size indicates a very limited scope, likely containing summary or key results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Likely generated from laboratory experiments profiling monoclonal antibodies against engineered Borrelia burgdorferi strains.

Freshness

Last updated 2026-04-21 17:52:17; freshness should be verified.