PFIC Genotype and Liver Transplantation Association Meta-Analysis Data

Rania Sakka's dataset contains extracted study characteristics for a meta-analysis on Progressive Familial Intrahepatic Cholestasis (PFIC). The data, last updated in June 2026, includes information from 18 studies involving 420 PFIC patients to investigate the association between null genotypes and liver transplantation outcomes. The analysis calculated an odds ratio of 2.79 for this association.

Use Cases

• Replicate the meta-analysis results based on the extracted study-level data.
• Investigate correlations between PFIC genotype categories and clinical outcomes mentioned in the description.
• Perform subgroup analysis by PFIC subtype as referenced in the study results.

Strengths

• Data is derived from a systematic review following PRISMA guidelines, suggesting a structured methodology.
• The dataset underpins a published meta-analysis with a specific calculated odds ratio (OR=2.79).
• It includes data from 18 studies and 420 patients, providing a defined scope for the analysis.

Limitations

• The dataset is very small at 17.5 KB, indicating limited raw data volume.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some analyses.

Provenance

Source

Rania Sakka via figshare.

Collection Method

Data extracted from published studies identified through a systematic literature search for a meta-analysis.

Freshness

Last updated 2026-06-01 17:50:38; freshness should be verified.