Characterization of Tablet Plug Formulations for Gastro-Retentive Drug Delivery

A dataset from figshare by Nilima Thombre, last updated in May 2026, characterizing a tablet-integrated superporous hydrogel drug delivery system. The data likely contains results from a 3² factorial design study evaluating formulations of Famotidine for ulcer treatment, including porosity, swelling index, and in vitro/in vivo drug release behavior. The optimized formulation (F1) achieved a cumulative drug release of 98.2191% and remained buoyant in the stomach for up to 12 hours.

Use Cases

• Optimizing drug formulation parameters based on concentrations of Crosspovidone and Cassia tora as independent variables.
• Modeling sustained drug release profiles based on in vitro and in vivo drug release behavior data.
• Analyzing the relationship between material properties like swelling ratio, void fraction, and porosity on gastric retention time.
• Evaluating drug-excipient compatibility for Famotidine formulations using FTIR and DSC analysis results.

Strengths

• Includes specific, quantified results for the optimized formulation, such as 98.2191% cumulative drug release and a 297.2% swelling ratio.
• Describes a structured experimental design using a 3² full factorial approach for formulation optimization.
• Contains data from multiple evaluation methods, including in vitro tests, in vivo radiographic studies, FTIR, and DSC.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating a limited scope focused on a specific experimental study.

Provenance

Source

figshare, author Nilima Thombre

Collection Method

Data likely generated from a laboratory study developing and testing a superporous hydrogel drug delivery system using a gas-blowing technique.

Freshness

Last updated 2026-05-08 17:45:30; freshness should be verified.