circVB16T13: Bactericidal Activity Against 19 Meningococcal Serogroup B Strains

Pooled serum from BALB/c mice immunized with circVB16T13 was evaluated for bactericidal activity against 19 Neisseria meningitidis serogroup B strains. Data are presented as geometric mean titers (GMTs) calculated from two or three technical replicates, with corresponding fHbp and NHBA genotypes, sequence types, and clonal complexes. The dataset was authored by Qiqi Zhang and last updated in May 2026.

Use Cases

• Compare bactericidal activity of a vaccine candidate against different meningococcal strains based on GMT values.
• Analyze the relationship between bactericidal activity and specific bacterial genotypes (fHbp, NHBA) listed in the dataset.
• Correlate bacterial clonal complexes (CC) and sequence types (ST) with serum killing efficacy.
• Benchmark experimental results against control (mock) group serum data included in the study.

Strengths

• Includes data for 19 distinct Neisseria meningitidis serogroup B strains.
• Provides associated genotypic data (fHbp, NHBA, ST, CC) for each strain.
• Data points are geometric mean titers (GMTs) calculated from two or three technical replicates.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (9.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental assay evaluating pooled mouse serum for bactericidal activity.

Freshness

Last updated 2026-05-11 18:00:43; freshness should be verified.

Geography

Strains are described as prevalent in China.