Clade Specificity of V2 Apex Antibodies: IC50s Against HIV-1 Viruses

19.8 KB of IC50 neutralization data for V2 apex antibodies against HIV-1 viruses from multiple clades. The dataset, authored by Bette Korber and last updated in April 2026, highlights the distinct neutralization patterns of antibodies like CAP256 VRC26.25 LS and PGDM1400 across B, C, and F clade viruses.

Use Cases

• Analyzing antibody neutralization breadth and potency based on IC50 values against different viral clades.
• Comparing clade-specific antibody efficacy based on patterns described for CAP256 VRC26.25 LS and PGDM1400.
• Investigating epitope region similarity across viral subtypes based on the described F-like behavior of B/F recombinants.

Strengths

• Data is focused on a specific immunological question regarding V2 apex antibodies and clade specificity.
• Includes results for multiple HIV-1 clades (B, C, F) and recombinant viruses as described.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 19.8 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Bette Korber, via figshare.

Collection Method

Likely derived from laboratory neutralization assays (AMP study).

Time Range

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Freshness

Last updated 2026-04-23 17:40:39; freshness should be verified.

Geography

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