<p>Clinical characteristics and BCVA summary.</p>

Yasuyuki Takai's dataset contains clinical characteristics and best-corrected visual acuity (BCVA) data for a cohort of patients with Leber hereditary optic neuropathy (LHON). It includes data from 27 patients (53 eyes) who presented within 6 months of onset and were followed continuously for at least 10 years at a tertiary eye hospital in Japan. BCVA measurements were collected from onset to 120 months, with piecewise linear mixed-effects models fitted over three clinical phases.

Use Cases

• Model long-term visual acuity trajectories based on the described three-phase piecewise linear analysis.
• Estimate cumulative probabilities of achieving specific BCVA thresholds (e.g., ≤1.6 logMAR) over a decade.
• Analyze visual outcome differences in a genetically confirmed LHON subgroup (m.11778G>A) mentioned in the description.
• Benchmark clinical progression in Asian LHON cohorts against other populations.

Strengths

• Includes longitudinal data with a minimum follow-up period of 10 years per patient.
• Focuses on a genetically confirmed, clinically defined cohort of 27 patients (53 eyes).
• Data is structured with patient- and eye-level random effects for statistical modeling.
• Uses a clear three-phase temporal model (Acute, Chronic, Late Chronic) for analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The modest sample size of 27 patients and selection of long-term attendees may limit generalizability, as noted by the author.

Provenance

Source

Yasuyuki Takai via figshare.

Collection Method

Single-center retrospective cohort study at a tertiary eye hospital in Japan.

Time Range

Data collection spans from patient onset to 120 months (10 years) of follow-up.

Freshness

Last updated 2026-04-28 17:27:14; freshness should be verified.

Geography

Data originates from a patient cohort in Japan.