Clinical Characteristics of Children with Sickle Cell Anaemia and Proteinuria in Nigeria

A dataset of 149 children with sickle cell anaemia and 149 matched controls from a publicly funded hospital in central Nigeria. It includes clinical measurements such as urine protein-creatinine ratio, serum creatinine, full blood count, and fetal hemoglobin, collected to study persistent proteinuria. The dataset was created by Angela Esohe Adeoti-Lawani and last updated in April 2026.

Use Cases

• Predicting risk of persistent proteinuria based on clinical markers like fetal hemoglobin levels.
• Comparing hematological and renal function profiles between children with sickle cell anaemia and matched controls.
• Analyzing determinants of early kidney damage using quantitative urine protein-creatinine ratio measurements.

Strengths

• Includes a control group of 149 age- and sex-matched participants for comparative analysis.
• Defines persistent proteinuria using a quantitative, repeated-measure method (urine protein-creatinine ratio ≥0.2 at two visits over at least 3 months).
• Reports a specific prevalence finding: 23.5% of children with SCA had persistent proteinuria versus 2.7% of controls.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single hospital in central Nigeria, which may limit generalizability.

Provenance

Source

Angela Esohe Adeoti-Lawani via figshare

Collection Method

Consecutive enrollment of children with SCA and matched controls at a publicly funded hospital; clinical measurements taken at first visit with follow-up for those with proteinuria.

Freshness

Last updated 2026-04-30 17:41:37; freshness should be verified.

Geography

Central Nigeria