Soluble Thrombomodulin Levels in 51 HFRS Patients

Clinical data from 51 patients with Hemorrhagic Fever with Renal Syndrome (HFRS) treated between January 2023 and January 2024. It tracks soluble thrombomodulin (sTM) levels across different disease phases and severity subtypes, correlating them with SOFA scores and mortality outcomes.

Use Cases

• Analyze the correlation between sTM levels and SOFA scores (R²=0.6076) for severity assessment in HFRS patients.
• Evaluate the predictive value of sTM for 28-day mortality risk using the identified cut-off value of 49.98 TU/mL.
• Compare sTM level trends across the febrile, hypotensive, and oliguria-dipuria phases of HFRS.
• Assess differences in sTM levels between survivor and non-survivor groups to identify prognostic biomarkers.
• Investigate the 'stepwise' increase in sTM levels across moderate, severe, and critical HFRS subtypes.

Strengths

• Data includes 51 HFRS patient records from a defined one-year study period (Jan 2023 - Jan 2024).
• Strong statistical correlation reported between sTM and SOFA scores (R²=0.6076, P<0.0001).
• Provides a specific sTM cut-off value (49.98 TU/mL) with reported sensitivity (81.36%) and specificity (100%) for mortality prediction.
• Analysis includes comparison across clinical phases (febrile, hypotensive, oliguria-dipuria) and four severity subtypes (mild, moderate, severe, critical).

Limitations

• Small sample size of 51 patients limits statistical power and generalizability of findings.
• Data is from a single hospital's Infectious Diseases Department, which may introduce geographic or institutional bias.
• Retrospective study design may be subject to selection bias and unmeasured confounding factors.

Provenance

Source

Infectious Diseases Department of the Second Affiliated Hospital of Air Force Medical University.

Collection Method

Retrospective analysis of patient medical records.

Time Range

January 2023 to January 2024.

Freshness

Data covers patients treated up to January 2024; metadata last updated March 2026.

Geography

Hospital location not specified; presumed China based on author and institution names.