<p>Clusters identified in the study.</p>

1,523 Klebsiella pneumoniae isolates from 27 neonatal units in 13 African and South Asian countries collected between 2013 and 2023. The dataset, created by Erkison Ewomazino Odih, identifies 156 nosocomial transmission clusters, estimating that 68.0% of neonatal infections were part of these clusters. It includes data on multi-locus sequence types and antimicrobial resistance gene carriage.

Use Cases

• Estimating the proportion of neonatal sepsis attributable to nosocomial transmission based on genetic and temporal clustering.
• Analyzing the association between specific antimicrobial resistance genes (e.g., ESBL, carbapenemase) and transmission likelihood.
• Identifying prevalent multi-locus sequence types (STs) and globally recognized multidrug-resistant lineages involved in outbreaks.
• Comparing transmission burden and cluster sizes across different neonatal care units and geographic regions.

Strengths

• Includes 1,523 bacterial whole-genome sequences from a multi-country study.
• Analysis covers a 10-year time range (2013-2023) across 27 units in 13 countries.
• Identifies 156 transmission clusters with defined genetic and temporal distance thresholds.
• Reports specific statistical associations, such as the adjusted odds ratio for carbapenemase gene carriage and transmission.

Limitations

• Lacks sufficient clinical data for high-resolution investigation of transmission dynamics.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• Facility-level data is absent, limiting investigation of contributors to differences in transmission burden across sites.

Provenance

Source

Aggregated from 10 contributing studies, author is Erkison Ewomazino Odih.

Collection Method

Single-linkage clustering based on pairwise temporal and genetic distances estimated from bacterial whole-genome sequences.

Time Range

2013 to 2023

Freshness

Last updated 2026-05-13 18:00:10; freshness should be verified.

Geography

13 countries in Africa and South Asia