<p>Comparison of genotype distribution of <i>TP53, CREBBP, KRAS, CDKN2A, IDH1, GZMB, KEAP1

A 5.5 KB Excel dataset by Rehab Osman Taha, last updated on 2026-05-08. It compares the genotype distribution of eight gene mutations across intrahepatic cholangiocarcinoma (iCCA), ovarian (OV), and healthy groups. Data are presented as counts (n), total samples analyzed (N), and mutation frequencies (%).

Use Cases

• Compare mutation frequencies of TP53, CREBBP, KRAS, CDKN2A, IDH1, GZMB, KEAP1, and NFE2L2 across iCCA, OV, and healthy groups based on the described genotype distribution.
• Identify potential driver mutations in intrahepatic cholangiocarcinoma (iCCA) and ovarian (OV) cancer based on the provided mutation counts and frequencies.
• Benchmark mutation prevalence for the listed genes in healthy control groups against cancer cohorts.
• Perform statistical analysis on genotype distribution using the provided sample numbers (n) and totals (N).

Strengths

• Data is structured for direct comparison across three distinct groups: iCCA, OV, and healthy.
• Provides mutation frequencies (%), which allows for relative prevalence analysis.
• The dataset is small (5.5 KB), facilitating quick download and initial inspection.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The description does not specify the sample size (N) for each group, limiting assessment of statistical power.
• Geographic or demographic source of the samples is not provided, which may indicate inherent bias.

Provenance

Source

figshare

Freshness

Last updated 2026-05-08 17:35:41; freshness should be verified.