Hippocampal Gene Expression in Pilocarpine-Induced Status Epilepticus Mice

Featuring RNA sequencing results from the hippocampus of pilocarpine-induced status epilepticus mice at 3-hour and 24-hour time points. It identifies 366 differentially expressed genes (DEGs) at the 3-hour point and 570 DEGs at the 24-hour point, with most being up-regulated. The data is provided in an XLSX file of 139.6 KB.

Use Cases

• Analyze the functional enrichment of the 570 SE-24h up-regulated genes in inflammatory and immune response pathways.
• Compare the expression profiles of specific DEGs like Tyrobp, C1qc, and Itgb2 between the SE-3h and SE-24h time points.
• Investigate the role of the 366 SE-3h DEGs in the early molecular changes following status epilepticus induction.
• Validate the involvement of the Microglia pathogen phagocytosis pathway using the identified up-regulated gene subset.

Strengths

• Identifies a specific count of 366 differentially expressed genes at the 3-hour time point.
• Identifies a specific count of 570 differentially expressed genes at the 24-hour time point.
• Focuses on a crucial stage of acute brain damage in a defined experimental model (pilocarpine-induced SE mice).

Limitations

• The dataset is very small in file size (139.6 KB), indicating limited scope and likely a summary of results rather than raw sequencing data.
• Sample size and number of biological replicates are unknown, limiting statistical power assessment.
• Data is restricted to two specific post-SE time points (3h and 24h), missing other potential critical time windows.

Provenance

Source

Author Hui-Ling Tang, published on figshare.

Collection Method

RNA sequencing of hippocampal tissue from pilocarpine-induced status epilepticus mice.

Time Range

Experimental observations at 3-hour and 24-hour post-SE induction.

Freshness

Last updated March 20, 2026.