Comprehensive Catalog of Cell Types: 77 Cell Types in 19 Human Lymph Nodes

A 2026 dataset by Maddalena M. Bolognesi provides a high-dimensional proteomic map of normal human lymph nodes. It classifies 77 cell types from 19 pathology-free lymph nodes using a 78-marker antibody panel and the MILAN staining method. The data includes spatial allocation and neighborhood analysis for T, B, innate immune, and stromal cells.

Use Cases

• Classifying T-cell subsets based on expression profiles of TCF7 and co-inhibitory receptors.
• Mapping the spatial distribution of B-cell types defined by CD5 and TCF7 expression.
• Analyzing statistically controlled pairwise neighborhood interactions to identify novel landscape niches.
• Studying the location of Type 2 conventional dendritic cells in paracortical aggregates.

Strengths

• Defines 77 distinct cell types from a specific tissue source.
• Based on data from 19 human lymph nodes, providing a multi-sample foundation.
• Utilizes a high-resolution 78-marker antibody panel for detailed proteomic interrogation.
• Includes spatial distribution data for cell types and interactions.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 30.5 KB, indicating limited scope or highly summarized data.

Provenance

Source

figshare

Collection Method

Hyperplexed cyclic staining method (MILAN) and analytical bioinformatic pipeline (BRAQUE) applied to human tissue samples.

Time Range

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Freshness

Last updated 2026-04-21 17:54:12; freshness should be verified.

Geography

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