LDL Cholesterol-Associated LDLR Variants After Conditional Analysis

23.1 KB of data on noncoding genetic variants near the LDLR gene, derived from a published genome-wide association study. The dataset, created by Kyle Leix and last updated in March 2026, likely contains significant associations for variants with an allele frequency greater than 1% within 500 kb of the transcription start site, after adjustment for linkage disequilibrium.

Use Cases

• Prioritizing noncoding variants for functional validation based on significant associations after conditional analysis.
• Studying the genetic architecture of LDL cholesterol levels in individuals of European ancestry.
• Identifying regulatory elements near the LDLR gene based on variant association signals.
• Training models to predict variant impact using association statistics before and after conditional adjustment.

Strengths

• Data is derived from a published genome-wide association study (Graham et al.), providing a credible source.
• Focuses on a specific genomic region (500 kb around LDLR) and a defined allele frequency threshold (>1%).
• Includes results from a specific statistical method (conditional analysis for linkage disequilibrium).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• Data is limited to individuals of European ancestry, which may limit generalizability.
• The dataset is very small (23.1 KB), indicating a limited scope of analysis.

Provenance

Source

figshare, author Kyle Leix.

Collection Method

Derived from association statistics in Graham et al. (PLOS Genetics).

Time Range

The temporal coverage of the underlying genetic study is not specified.

Freshness

Last updated 2026-03-17 17:32:00; freshness should be verified.

Geography

Data is from individuals of European ancestry; specific countries are not stated.