Retinal Microvascular Metrics in Hyperglycemic Mice, 7-61 Weeks

Data from a study tracking retinal microvascular changes in male Ins2Akita x NG2DSRed mice (n=14) aged 7–61 weeks under sustained hyperglycemia, compared to euglycemic controls (n=13). The dataset, authored by Fei Shang and last updated in May 2026, includes metrics like vessel density, branching, length, tortuosity, pericyte density, and plexus connectivity. It also contains longitudinal imaging data from one mouse tracked for 12 weeks using an adaptive optics scanning light ophthalmoscope.

Use Cases

• Analyze correlations between blood glucose levels and retinal vessel density, branching, and tortuosity.
• Compare vascular patterning metrics between hyperglycemic and euglycemic control mice.
• Study pericyte density and vascular plexus connectivity changes over time in a diabetic mouse model.
• Validate in vivo ophthalmoscopy-accessible metrics against ex vivo confocal microscopy data.

Strengths

• Includes data from 27 mice (14 hyperglycemic, 13 control) providing a comparative basis.
• Contains longitudinal tracking of one mouse over a 12-week period from 24–36 weeks of age.
• Analyzes multiple specific vascular metrics: vessel density, branching, length, tortuosity, pericyte density, and plexus connectivity.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (86.1 KB), indicating limited scope and likely a focused experimental dataset.

Provenance

Source

Fei Shang via figshare.

Collection Method

Retinal flat mounts were imaged using confocal microscopy; one mouse was longitudinally imaged using an adaptive optics scanning light ophthalmoscope (AOSLO).

Time Range

Mouse ages 7–61 weeks, with longitudinal imaging from 24–36 weeks.

Freshness

Last updated 2026-05-28 17:30:07; freshness should be verified.