CT2-lgDel: Functional Enrichment Clusters for Prader-Willi Syndrome Research

CT2-lgDel functional enrichment clusters are a dataset from a study mapping Prader-Willi Syndrome (PWS) gene expression data onto a human protein-protein interaction network. The dataset, created by Kunal Bham and last updated in April 2026, contains results from a graph learning analysis identifying impacted proteins and altered biological processes in PWS. It is a 5.5 KB XLS file shared under a CC-BY-4.0 license.

Use Cases

• Identifying candidate proteins with altered expression in Prader-Willi Syndrome based on network embedding differences.
• Analyzing enrichment of glycosylation pathways and homeobox proteins in disease mechanisms.
• Validating network-based methods like GeneEMBED for application to other complex diseases.

Strengths

• Results are described as highly reproducible across PWS model systems.
• Dataset is derived from an integrated analysis of expression data and a protein-protein interaction network.
• File size is 5.5 KB, indicating a focused and likely well-defined output.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Kunal Bham via figshare

Collection Method

Generated by integrating PWS gene expression data with a protein-protein interaction network, calculating node embeddings, and performing functional enrichment analysis.

Freshness

Last updated 2026-04-28 17:24:04; freshness should be verified.