CTL Epitope Screening Results for Bat HKU5-CoV-2 Vaccine Design

Ningze Zheng's dataset contains cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and linear B lymphocyte (LBL) epitopes screened from the spike glycoprotein of the bat-infecting merbecovirus BtHKU5-CoV-2. The 9.5 KB XLS file, last updated in April 2026, presents results from an immunoinformatics study that designed a multi-epitope mRNA vaccine candidate. The data includes in silico analyses of predicted antigenicity, immunogenicity, and molecular docking with Toll-like receptors.

Use Cases

• Training epitope prediction models based on the eight CTL, seven HTL, and five LBL epitopes identified.
• Benchmarking vaccine construct designs based on the described multi-epitope assembly with linkers, β-defensin II, and MHC I-targeting domain.
• Analyzing predicted interactions between vaccine candidates and immune receptors based on the molecular docking results with TLR2, TLR3, TLR4, TLR7, and TLR8.

Strengths

• Includes a specific count of screened epitopes: eight CTL, seven HTL, and five LBL.
• Dataset is openly available under a CC-BY-4.0 license.
• Results are derived from a described immunoinformatics pipeline, including molecular docking and immune simulation.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• All findings are from in silico analyses; the description notes further experiments are necessary to validate protective efficacy.
• The dataset is very small at 9.5 KB, indicating limited scope.

Provenance

Source

figshare, authored by Ningze Zheng.

Collection Method

Epitopes were screened from the spike glycoprotein of BtHKU5-CoV-2 using an immunoinformatics approach; vaccine construct was designed and analyzed in silico.

Time Range

Study period is not specified.

Freshness

Last updated 2026-04-03 17:42:40.

Geography

Geographic coverage is not specified.