Tuberculosis Outcomes in Mexican Patients with Chronic Kidney Disease

A collection of a cohort of 51 tuberculosis patients from Mexico, with 17 having advanced chronic kidney disease (ACKD) and 34 without. It compares mortality, cure, and relapse rates between these groups from 2013 to 2024. The data includes information on patient characteristics, treatment regimens, and outcomes.

Use Cases

• Compare all-cause mortality and TB-related mortality rates between ACKD and non-ACKD patient groups.
• Analyze cure rates for tuberculosis in patients with lupus or diabetes as causes of CKD.
• Examine the use and outcomes of the local pragmatic alternating treatment regimen received by 68% of CKD patients.
• Perform a sensitivity analysis on mortality outcomes by excluding HIV-positive patients from the cohort of 44.

Strengths

• Data covers a specific, clinically relevant population of 51 TB patients with and without advanced CKD.
• Includes a sensitivity analysis on a subset of 44 patients excluding HIV-positive individuals.
• Provides real-world evidence from a Latin American setting (Mexico) over an 11-year period (2013-2024).

Limitations

• Very small sample size of 51 total patients limits statistical power and generalizability.
• The study notes a low event rate, preventing multivariate analysis and robust statistical conclusions.
• Findings are preliminary and lack pharmacokinetic validation of the treatment regimens used.

Provenance

Source

Observational-analytical study from a tertiary care center in Mexico.

Collection Method

Patients aged ≥18 years with microbiologically or histologically confirmed TB were included and compared based on kidney function (GFR).

Time Range

2013 to 2024

Freshness

Data collection spans 2013 to 2024, with the record last updated in March 2026.

Geography

Mexico