HCMV and TB Association Study Data from South African Adults

98 tuberculosis cases and 199 controls from a cross-sectional study in Cape Town, South Africa, were analyzed for HCMV infection status. The dataset, created by Derrick Semugenze and last updated in May 2026, includes results from qPCR and serology (IgM and IgG avidity ELISA) tests. Logistic regression analysis found an adjusted odds ratio of 4.99 for the association between TB disease and HCMV DNAemia.

Use Cases

• Assessing the association between active HCMV infection and TB disease based on qPCR and serology results.
• Investigating potential immune impairment mechanisms in TB patients with HCMV co-infection.
• Replicating the logistic regression analysis adjusting for age, gender, HIV status, and BMI.
• Studying the epidemiology of HCMV and TB in a South African adult population.

Strengths

• Includes 297 total participant records (98 TB cases and 199 controls).
• Data is frequency-matched by HIV status, a key confounder.
• Uses multiple diagnostic methods (qPCR, IgM and IgG avidity ELISA) to define HCMV infection status.
• Analysis includes adjusted odds ratios with confidence intervals and p-values.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a specific cross-sectional study in one district, limiting generalizability.

Provenance

Source

figshare

Collection Method

Stored plasma and serum samples collected from adults self-presenting to primary care clinics in the Kraaifontein District, Cape Town.

Freshness

Last updated 2026-05-19 17:25:46; freshness should be verified.

Geography

Kraaifontein District, Cape Town, South Africa.