Murine Model Data for Artemether Hepatoprotective Effects in Type 1 Diabetes

Qike Fu's dataset contains experimental data evaluating the hepatoprotective effects of Artemether in a murine model of Type 1 Diabetes Mellitus. The data includes histopathological evaluations, mitochondrial ultrastructure images, gene/protein expression levels, and quantitative metabolic intermediate analysis via UPLC-QQQ-MS/MS. The dataset was last updated on 2026-04-29 and is shared under a CC-BY-4.0 license.

Use Cases

• Analyze correlations between Artemether administration and attenuation of diabetic manifestations based on described experimental results.
• Study the preservation of mitochondrial morphology and respiratory chain complex protein expression based on transmission electron microscopy and molecular analysis data.
• Investigate the regulation of hepatic glucose and lipid metabolic pathways based on quantified metabolic intermediates and expression markers.
• Validate findings on intrahepatic triglyceride concentration normalization and downregulation of gluconeogenesis/glycogenolysis key molecules.

Strengths

• Data integrates multiple analysis levels: histopathological, ultrastructural, molecular, and metabolomic.
• Metabolic intermediates were quantitatively analyzed using ultra-high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-QQQ-MS/MS).
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Dataset is small at 56.9 KB, indicating limited scope.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• Data is from a specific murine model study; generalizability to humans is unclear.

Provenance

Source

Author Qike Fu, shared via figshare.

Collection Method

Data generated from a laboratory study involving a murine model of Type 1 Diabetes Mellitus, with Artemether administration and subsequent multi-modal analysis.

Freshness

Last updated 2026-04-29 17:44:20; freshness should be verified.