Systematic Review Protocol for Fatigue Interventions in Chronic Kidney Disease

A protocol for a systematic review evaluating interventions for fatigue in chronic kidney disease, a condition affecting approximately 850 million people worldwide. The review, authored by Hannah Mary Louise Young, will synthesize evidence from multiple databases without language or date restrictions. It outlines methods for study selection, data extraction, and evidence synthesis, including potential meta-analysis.

Use Cases

• Designing future clinical trials based on identified evidence gaps for fatigue management in CKD.
• Informing clinical practice guidelines, specifically the UK Kidney Association Symptom Guidelines, based on synthesized intervention efficacy.
• Assessing the risk of bias in existing studies on CKD fatigue using standardized tools like NIH Study Quality Assessment Tools.
• Conducting meta-analyses on the efficacy of pharmacological and non-pharmacological interventions for fatigue where data permits.

Strengths

• The protocol is explicitly licensed under CC-BY-4.0, allowing for broad reuse and adaptation.
• Search strategy is comprehensive, covering six major databases and grey literature with no language or publication date restrictions.
• Methodology is detailed, specifying a two-stage screening process with independent reviewers and standardized data extraction.

Limitations

• The dataset is a 9.5 KB protocol document; it does not contain the actual review data or results.
• Row count and column-level documentation for any extracted data are unknown, limiting suitability assessment for direct analysis.
• The described systematic review is a planned future work; the available file likely contains only the methodological plan.

Provenance

Source

figshare

Collection Method

Protocol document outlining methods for a planned systematic review and meta-analysis.

Freshness

Last updated 2026-05-05 17:27:46; freshness should be verified as this is a future date.