Experimental Data on Mutual Solubility Enhancement of Rosiglitazone and Ibuprofen

A dataset from figshare by Yaxiang Gong, published in March 2026, quantifying the mutual solubility enhancement of two drugs. The 1.5 MB dataset contains results from HPLC solubility measurements, fluorescence and FT-IR spectroscopy, and molecular dynamics simulations. It reports solubility increases of 6–16% for rosiglitazone and 11–27% for ibuprofen across a temperature range of 30–60 °C.

Use Cases

• Modeling drug-drug solubility interactions based on experimental solubility measurements.
• Training models to predict solvent-solute compatibility using molecular dynamics simulation results.
• Analyzing spectroscopic data (fluorescence, FT-IR) to detect ground-state molecular associations.
• Developing formulation strategies for poorly water-soluble drugs based on mutual solubilization phenomena.

Strengths

• Includes specific, quantified solubility results (e.g., rosiglitazone solubility rose from 60.4–79.9 to 69.2–92.4 μg/mL).
• Combines experimental data (HPLC, spectroscopy) with computational insights from molecular dynamics simulations.
• Data is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is packaged in a RAR archive, which may require specific software to extract.

Provenance

Source

figshare, author Yaxiang Gong.

Collection Method

Data generated from laboratory experiments (HPLC, spectroscopy) and computational simulations (molecular dynamics).

Time Range

Experimental data covers a temperature range of 30–60 °C.

Freshness

Last updated 2026-03-18 17:30:20; freshness should be verified.