Biochemical Analyses of Cholesterol Diet Effects in Hypertensive Rats

Yutaro Nishikata's dataset contains biochemical measurements from a study on stroke-prone spontaneously hypertensive rats (SHRSP). The data, last updated in May 2026, includes sterol content, fatty acid composition, prostaglandin E2 levels, and renal histopathology results from rats fed cholesterol-enriched and control diets over a 12-week period.

Use Cases

• Analyzing the relationship between dietary cholesterol and systolic blood pressure based on the reported 9–10% reduction.
• Investigating changes in lipid profiles, including phytosterol content and arachidonic acid ratios, in serum and kidney tissue.
• Studying the suppression of the AA-PGE2 axis in relation to renal pathology and inflammation.
• Comparing biochemical outcomes between cholesterol-fed groups and groups also treated with lovastatin.

Strengths

• Data is associated with a specific, detailed experimental protocol involving three diet groups over 12 weeks.
• Includes multiple biochemical analyses: sterol content, fatty acid composition, PGE2 levels, and histopathology.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (10.2 KB), indicating a limited scope of observations.

Provenance

Source

Yutaro Nishikata via figshare

Collection Method

Experimental data collected from a controlled animal study.

Time Range

Study period involved a 12-week feeding trial.

Freshness

Last updated 2026-05-21 17:26:47; freshness should be verified.