Real-Time RT-PCR Data from a Cholesterol Diet Study in Hypertensive Rats

A 14.8 KB dataset from a study examining the paradoxical effects of dietary cholesterol on stroke-prone hypertensive rats. The data, published by Yutaro Nishikata on figshare under CC-BY-4.0, includes measurements of sterol content, fatty acid composition, prostaglandin E2 levels, and systolic blood pressure. The study found a 9–10% reduction in systolic blood pressure in rats fed a cholesterol-enriched diet.

Use Cases

• Analyzing the relationship between dietary cholesterol and systolic blood pressure changes based on the reported 9–10% reduction.
• Investigating lipid profile alterations, including phytosterol content and arachidonic acid ratios, in serum and kidney tissue.
• Studying the suppression of the AA-PGE2 axis in relation to renal pathology and inflammation as described in the mechanistic framework.

Strengths

• Data is associated with a specific, peer-reviewed experimental design involving three distinct diet groups (control, cholesterol, cholesterol+lovastatin).
• The dataset includes multiple biological measurements: systolic blood pressure, sterol content, fatty acid composition, and prostaglandin E2 levels across different tissues.
• It is published under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• The dataset is very small at 14.8 KB, indicating limited scope and likely a small number of observations.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare, authored by Yutaro Nishikata.

Collection Method

Data was generated from a controlled laboratory experiment on stroke-prone spontaneously hypertensive rats (SHRSP/Izm).

Freshness

Last updated 2026-05-21 17:26:48; freshness should be verified.