Enterococcus faecalis c-di-AMP Signaling and Immune Response Data

A 2026 dataset by Adriana G. Morales Rivera characterizes the EecP enzyme in Enterococcus faecalis, which degrades the extracellular signaling molecule c-di-AMP. The data includes results from competition experiments, phagocyte susceptibility assays, NanoString analysis of murine macrophage immune signatures, and outcomes from two murine infection models. It is shared under a CC-BY-4.0 license via figshare.

Use Cases

• Modeling bacterial immune evasion based on extracellular c-di-AMP degradation activity.
• Analyzing host immune response signatures based on NanoString data from infected macrophages.
• Comparing infection severity based on data from two murine infection models.
• Investigating enzyme substrate specificity based on competition experiment results with c-di-GMP and AMP.

Strengths

• Data is associated with a specific, novel enzyme (EecP) characterization.
• Includes results from multiple experimental approaches: enzyme assays, cell-based assays, and animal models.
• License is permissive (CC-BY-4.0).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.6 MB size suggests a relatively small dataset.

Provenance

Source

Adriana G. Morales Rivera

Collection Method

Likely contains experimental data from microbiology and immunology laboratory studies.

Freshness

Last updated 2026-05-21 07:38:17; freshness should be verified.