Sex-Specific Determinants of IL-17A Cytokine Levels in a Zambian Clinical Cohort

A Zambian cross-sectional study of 225 adults (71 males, 154 females) from Livingstone University Teaching Hospital, investigating sociodemographic, clinical, and inflammatory correlates of circulating Interleukin-17A (IL-17A). The dataset was created by David Chisompola and last updated on 2026-05-18. It identifies distinct sex-specific determinants, with IL-17A associated with an inflammatory cytokine network in males and plasma potassium levels in females.

Use Cases

• Analyze sex-specific associations between IL-17A and other inflammatory cytokines like IL-6 and IL-1β based on the regression results described.
• Investigate the relationship between plasma potassium levels and IL-17A in female participants as indicated in the study findings.
• Examine the lack of association between HIV status and IL-17A levels in the studied cohort based on the reported regression analysis.
• Study the demographic and clinical correlates of a key Th17 cytokine in a sub-Saharan African adult population.

Strengths

• Includes data from 225 participants with detailed sex-stratified analysis (71 males, 154 females).
• Contains measured plasma levels of IL-17A and a panel of other inflammatory cytokines.
• Collects sociodemographic, metabolic, clinical, and HIV/ART regimen data for each participant.
• Analysis uses sex-stratified multiple linear regression models with statistical significance (p<0.05).

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is small (74.7 KB), indicating a limited scope and sample size.
• Data is from a single hospital in Zambia, which may limit generalizability to other populations.

Provenance

Source

David Chisompola via figshare

Collection Method

Cross-sectional study with plasma cytokine measurements and clinical data collection from a hospital cohort.

Freshness

Last updated 2026-05-18 17:40:33; freshness should be verified.

Geography

Livingstone University Teaching Hospital, Zambia