Pediatric Epilepsy Sleep and Seizure Response to Perampanel

Clinical trial data from a single-center study of 31 children with Self-Limited Epilepsy with Centrotemporal Spikes. The dataset records seizure frequency, sleep architecture from EEG, and subjective sleep quality scores at baseline, 1-month, and 2-month intervals after initiating Perampanel treatment. Biao Jiang authored the dataset, which was published on figshare in April 2026.

Use Cases

• Analyze temporal changes in monthly_seizure_frequency and Spike-Wave_Index (SWI) across three time points to model treatment response curves.
• Correlate EEG-derived sleep_stage_durations (N1, N3, REM) with subjective Children’s_Sleep_Habits_Questionnaire (CSHQ) scores to validate objective vs. perceived sleep quality.
• Identify early predictors of treatment success by modeling if early improvements in CSHQ_score or N1_duration predict later reductions in seizure_frequency.
• Assess tolerability by analyzing the incidence of adverse_events reported across the 2-month study period.

Strengths

• Longitudinal design with measurements at three specific time points (baseline, 1 month, 2 months).
• Includes multiple data modalities: clinical seizure counts, objective EEG sleep architecture, and validated questionnaire (CSHQ) scores.
• Reported a high response rate with 93.5% of children achieving ≥50% reduction in seizure frequency.

Limitations

• Small sample size of 31 patients from a single center, limiting statistical power and generalizability.
• Short observational period of 2 months may not capture long-term effects or stability of improvements.
• Dataset is very small at 43.5 KB, indicating limited scope and likely a summary or aggregated data view.

Provenance

Source

Single-center retrospective observational study by author Biao Jiang.

Collection Method

Clinical assessments including 24-hour ambulatory EEG, CSHQ questionnaires, and seizure frequency logs.

Time Range

Measurements taken at baseline, 1 month, and 2 months after Perampanel initiation.

Freshness

Data last updated in April 2026, representing recent research.

Geography

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