Data: Physiological and Pathological Indicators from MSU-Induced Gouty Arthritis Rat Study

Physiological and pathological data from a study of acute gouty arthritis in rats induced by monosodium urate crystals. The dataset includes measurements from rats treated with the HDAC3 inhibitor RGFP966 or colchicine, assessing gait scores, swelling, cytokine levels, and protein markers related to the AIM2 inflammasome and mitophagy. It was authored by Zewei Wang and last updated on May 14, 2026.

Use Cases

• Analyze the effect of RGFP966 on inflammatory cytokine levels (IL-1β, IL-18, IL-6, TNF-α) in a rat model of gout.
• Investigate the relationship between HDAC3 inhibition and AIM2 inflammasome protein markers (AIM2, Pro-caspase-1, Cleaved-caspase-1, ASC) in synovial tissue.
• Study the impact of RGFP966 on mitochondrial function and mitophagy markers (Pink1, Parkin, LC3-II, ROS, ATP, MMP) in gout pathology.

Strengths

• Dataset is licensed under CC-BY-4.0, allowing for broad reuse.
• The description details a specific experimental design comparing RGFP966 to colchicine treatment in a rat model.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 153.7 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory experiments on MSU-induced acute gouty arthritis in rats, involving physiological scoring, ELISA, Western blot, and immunofluorescence assays.

Freshness

Last updated 2026-05-14 17:34:47; freshness should be verified.