Cardiac Neuron Atlas from 120 Heart Failure Patients and Healthy Donors

Encompassing a cardiac neuron landscape of 11,026 neuronal cells derived from single-nucleus RNA sequencing data of 75 heart failure patients and 45 healthy donors. It identifies ten distinct neuronal cell subsets, including N4-ALK neurons enriched in failing hearts, and features related to transcriptional regulatory networks and cell crosstalk.

Use Cases

• Analyze the abundance and composition of ten distinct neuronal cell subsets, such as N4-ALK neurons, across heart failure patients and healthy donors.
• Investigate the PTN-PTPRZ1 axis mediating crosstalk between cardiac fibroblasts and N4-ALK neurons in heart failure.
• Develop a prediction model for heart failure using N4-ALK-related features derived from the neuronal atlas.
• Examine the role of the transcription factor RXRG in the transcriptional regulatory network of N4-ALK neurons and its correlation with marker gene expression.
• Assess the association between N4-ALK neuron abundance and the clinical response to left ventricular assist device implantation.

Strengths

• Integrates single-nucleus RNA sequencing data from a cohort of 120 individuals (75 patients and 45 donors).
• Characterizes 11,026 neuronal cells, identifying ten distinct subsets with differing biological functions.
• Includes analysis of specific neuronal subsets like N4-ALK neurons and their association with heart failure pathology.

Limitations

• The dataset is small in file size (12.7 KB), suggesting it contains processed summary or feature data rather than raw sequencing data.
• The specific data structure, columns, and sample data are not provided, limiting immediate analytical utility.
• The temporal and geographic coverage of the source patient data is not specified.

Provenance

Source

Integration of published single-nucleus RNA sequencing data.

Collection Method

Bioinformatic analysis of integrated sequencing data to generate a neuronal cell landscape.

Time Range

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Freshness

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Geography

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