<p>Data Summary.</p>

Proteomic, bulk RNA sequencing, and single-cell RNA sequencing data were analyzed to assess changes in S100A4 abundance in response to Angiotensin II infusion in mice. The dataset, authored by Sohei Ito and last updated on 2026-05-12, is stored in an XLSX file of 15.9 KB. It supports a study concluding that S100A4-lineage cells modestly contribute to AngII-mediated thoracic aortic aneurysm development through the AT1aR receptor.

Use Cases

• Analyze S100A4 protein abundance changes based on proteomic data mentioned in the description
• Investigate cell-type-specific gene expression based on single-cell RNA sequencing data mentioned in the description
• Study lineage tracing of S100A4-positive cells based on the experimental methods described
• Model Angiotensin II-induced vascular remodeling based on the described mouse infusion experiments

Strengths

• Data integrates multiple omics layers: proteomic, bulk RNA-seq, and single-cell RNA-seq
• Dataset is openly licensed under CC-BY-4.0 for reuse

Limitations

• Dataset is very small at 15.9 KB, indicating limited scope
• Row count and column-level documentation are unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Data generated from mouse model experiments involving Angiotensin II infusion and genetic lineage tracing.

Freshness

Last updated 2026-05-12 17:45:31