TDP-43 Aggregation and Cryptic Exon Splicing Biosensor Data

Experimental data from a human cell biosensor model used to study TDP-43 protein aggregation and its functional consequences in neurodegenerative disease. The dataset supports figures 1E through 1G in the associated research, illustrating connections between aggregation seeding, nuclear TDP-43 depletion, and cryptic exon splicing. It was authored by Lohany Dias Mamede and shared under a CC BY 4.0 license in March 2026.

Use Cases

• Analyze the correlation between TDP-43 aggregate seeding and the activation of cryptic exon splicing events.
• Model the progressive depletion of nuclear TDP-43 localization following prion-like seeding initiation.
• Investigate the impact of ataxin-2 level modulation on TDP-43 aggregation and activity restoration.

Strengths

• Data is directly tied to published research figures (Fig 1E-1G), ensuring relevance to a specific biological model.
• Focuses on a quantitative cell-based reporter for TDP-43 aggregation and loss-of-function, a key mechanism in fatal neurodegenerative disorders.
• Shared under a permissive CC BY 4.0 license, facilitating open reuse and redistribution.

Limitations

• The dataset is very small at 10.1 KB, indicating limited scope and likely containing only summary or illustrative data points rather than raw experimental replicates.
• No column definitions or sample data are provided, making the exact structure and variables opaque to potential users.
• Data is derived from a specific, controlled cell line model, which may not fully capture the complexity of TDP-43 pathology in human patients or animal models.

Provenance

Source

Figshare, authored by Lohany Dias Mamede.

Collection Method

Generated from a quantitative human biosensor cell line experiment measuring TDP-43 aggregation and functional readouts.

Freshness

Last updated March 2026.