TDP-43 Aggregation and Dysfunction Reporter Data

Experimental data used to generate Figure 2C in a study of TDP-43 protein pathology. The dataset, provided by author Lohany Dias Mamede, supports analysis of a cell-based reporter system measuring TDP-43 aggregation and loss of function. It is a small dataset stored in an XLSX file with a size of 9.1 KB.

Use Cases

• Analyze the relationship between TDP-43 aggregation seeding and the activation of cryptic exon splicing.
• Model the impact of aggregate seeding on TDP-43 autoregulation and nuclear depletion.
• Investigate the effect of reducing ataxin-2 levels on TDP-43 aggregation and activity restoration.

Strengths

• Data directly supports a published scientific figure (Fig 2C) on a key neurodegenerative disease mechanism.
• Dataset is openly licensed under CC BY 4.0, permitting reuse and redistribution.
• Focuses on a quantitative cell-based reporter for TDP-43 aggregation and dysfunction.

Limitations

• The dataset is very small at 9.1 KB, indicating limited scope and likely insufficient for standalone statistical modeling.
• No column names, row counts, or sample data are provided, making the structure and content opaque.
• Data is specific to a single experimental setup and figure, limiting generalizability.

Provenance

Source

figshare, authored by Lohany Dias Mamede.

Collection Method

Generated from a cell-based reporter assay in a study of TDP-43 protein pathology.

Freshness

Last updated on 2026-03-24.