TDP-43 Aggregation and Dysfunction Reporter Cell Line Data

Data from a 2026 study characterizing a cell-based reporter for TDP-43 aggregation and loss-of-function in neurodegenerative disease models. The dataset, provided in XLSX format, is 12.7 KB and was authored by Lohany Dias Mamede. It supports analysis of seeding-induced cryptic exon splicing, DNA damage, and nuclear TDP-43 depletion.

Use Cases

• Analyze the relationship between TDP-43 aggregate seeding and the activation of cryptic exon splicing in reporter cells.
• Quantify changes in nuclear TDP-43 localization following prion-like seeding to model loss-of-function.
• Correlate seeding-induced DNA damage measurements with other markers of TDP-43 dysfunction.
• Investigate the impact of ataxin-2 level modulation on aggregate formation and TDP-43 activity restoration.

Strengths

• Data is directly associated with a 2026 peer-reviewed research publication, ensuring scientific relevance.
• The 12.7 KB XLSX file is a compact, structured format suitable for immediate analysis.

Limitations

• The dataset is very small (12.7 KB), indicating limited scope and likely a small number of experimental observations.
• Specific column names, row counts, and sample data are unavailable, hindering a precise assessment of structure and volume.

Provenance

Source

Figshare, authored by Lohany Dias Mamede.

Collection Method

Generated from a human biosensor cell line reporter assay measuring TDP-43 aggregation and functional readouts.

Time Range

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Freshness

Last updated on March 24, 2026.

Geography

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