TDP-43 Aggregation and Dysfunction Reporter Cell Line Data

Data from a 2026 study characterizes a cell-based reporter for TDP-43 aggregation and loss of function in neurodegenerative disease models. The dataset supports figures 4B-4D and 4F-G from the associated publication, with measurements related to cryptic exon splicing, DNA damage, and nuclear TDP-43 localization. It is provided in a 16.9 KB XLSX file under a CC BY 4.0 license by author Lohany Dias Mamede.

Use Cases

• Analyze the relationship between TDP-43 aggregate seeding and the activation of cryptic exon splicing events.
• Correlate measurements of nuclear TDP-43 depletion with indicators of increased DNA damage.
• Model the impact of ataxin-2 level modulation on TDP-43 aggregation and activity restoration.
• Investigate TDP-43 autoregulation and homeostasis disruption in a seeding-based pathology model.

Strengths

• Data is directly linked to a 2026 peer-reviewed publication, ensuring scientific relevance.
• Focuses on a quantitative cell-based reporter for a key pathology in ALS, FTD, and LATE.
• Includes measurements from disease-relevant human neuron models.

Limitations

• The dataset is very small at 16.9 KB, indicating limited scope and likely few data points.
• Specific row counts, column structures, and sample data are unavailable, hindering preliminary assessment.
• Data is generated from a specific experimental cell line model, which may not capture full in vivo complexity.

Provenance

Source

Figshare, authored by Lohany Dias Mamede.

Collection Method

Generated from experiments using a human biosensor cell line and neuronal models to study TDP-43 aggregation.

Freshness

Last updated on 2026-03-24.