TDP-43 Aggregation Reporter Data for Fig 5B

Figshare data from Lohany Dias Mamede supports a 2026 study on TDP-43 protein pathology. The dataset underpins Figure 5B, illustrating the impact of aggregate seeding on TDP-43 autoregulation. It is a small, 10.5 KB XLSX file with unspecified row and column counts.

Use Cases

• Analyze the relationship between aggregate seeding and TDP-43 autoregulation as shown in Fig 5B.
• Investigate the effect of ataxin-2 level reduction on TDP-43 aggregation and activity restoration.
• Examine data linking TDP-43 aggregation to downstream effects like increased DNA damage and cryptic exon splicing.

Strengths

• Data is directly tied to a specific published figure (Fig 5B) from a 2026 study.
• Dataset is shared under a permissive CC BY 4.0 license for reuse.
• Focuses on a quantitative cell-based reporter for TDP-43 aggregation and dysfunction.

Limitations

• The dataset is very small at 10.5 KB, indicating limited scope and likely a summary or figure source.
• Column names and sample data are unavailable, hindering immediate analysis without consulting the source publication.
• Data is a static snapshot supporting a single figure, not a large-scale experimental dataset.

Provenance

Source

Lohany Dias Mamede via figshare.

Collection Method

Generated from a human biosensor cell line reporter assay for TDP-43 aggregation and function.

Freshness

Last updated March 24, 2026.