TDP-43 Aggregation Reporter Data for Neurodegenerative Disease Research

2026-03-24 data from a human biosensor cell line study on TDP-43 pathology in neurodegenerative disorders. The dataset supports findings on aggregate seeding, nuclear TDP-43 depletion, and cryptic exon splicing. It is provided in an XLSX file under a CC BY 4.0 license by author Lohany Dias Mamede.

Use Cases

• Analyze the correlation between TDP-43 aggregate seeding and increased DNA damage measurements.
• Model the relationship between nuclear TDP-43 depletion levels and cryptic exon splicing activation.
• Quantify the impact of ataxin-2 level reduction on TDP-43 activity restoration metrics.

Strengths

• Data is recent, last updated on 2026-03-24.
• Derived from a human biosensor cell line, a disease-relevant model.
• Explicitly linked to published figures (Fig 7B–7C) for validation.

Limitations

• Very small dataset at 25.4 KB, indicating limited sample size.
• Column structure and row count are unknown, hindering immediate analysis.
• Scope is narrowly focused on a specific experimental reporter system.

Provenance

Source

figshare, author Lohany Dias Mamede.

Collection Method

Generated from a cell-based reporter assay capturing TDP-43 aggregation and loss of function.

Time Range

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Freshness

2026-03-24

Geography

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