Hypervirulent Klebsiella Pneumoniae Mouse Colonization and Translocation Data

Giovanna E. Hernandez published data used to generate figures for a study on hypervirulent Klebsiella pneumoniae (hvKP) pathogenesis on April 13, 2026. The 113.7 KB Excel file contains experimental results from a murine gastrointestinal colonization model comparing a clinical hvKP isolate to an aerobactin biosynthesis mutant. The data supports findings on the role of aerobactin in bacterial translocation across the intestinal epithelium.

Use Cases

• Analyze bacterial translocation from the GI tract to extra-intestinal organs based on in vivo mouse model data
• Compare virulence between wild-type and mutant bacterial strains based on organ burden measurements
• Investigate the relationship between aerobactin production and hypermucoviscosity (HMV) based on phenotypic assay results
• Model transcellular routes of bacterial invasion based on cell culture adhesion and invasion assays

Strengths

• Data is directly linked to a specific, peer-reviewed research study on hvKP pathogenesis
• Includes comparison of isogenic strains (wild-type vs. iucA- mutant) for controlled analysis
• File size is 113.7 KB, indicating a focused and likely manageable dataset

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download
• The dataset is very small (113.7 KB), indicating limited scope and sample size
• Data may reflect the specific experimental conditions and mouse model bias inherent to the original study

Provenance

Source

Giovanna E. Hernandez via figshare

Collection Method

Data generated from a murine gastrointestinal colonization model and cell culture assays for a specific research study.

Freshness

Last updated 2026-04-13 18:00:18