TDP-43 Aggregation and Dysfunction Reporter Cell Line Data

Experimental data from a human biosensor cell line study on TDP-43 protein aggregation and its functional consequences in neurodegenerative disease. The dataset includes measurements related to cryptic exon splicing, DNA damage, and nuclear TDP-43 depletion. It was authored by Lohany Dias Mamede and published on figshare in 2026 under a CC BY 4.0 license.

Use Cases

• Analyze the correlation between TDP-43 aggregate seeding and the activation of cryptic exon splicing in reporter cells.
• Model the relationship between nuclear TDP-43 depletion and the induction of DNA damage as a signature of diminished TDP-43 activity.
• Investigate the impact of ataxin-2 level reduction on TDP-43 aggregation and activity restoration using the seeding model data.

Strengths

• Data is directly linked to a published scientific figure (S3B–S3C Fig), ensuring relevance to a specific research finding.
• The dataset is small (12.4 KB) and in XLSX format, making it immediately accessible for quick review and analysis.

Limitations

• The dataset is extremely small (12.4 KB), indicating a very limited scope likely containing only summary or illustrative data points.
• No column names, row counts, or sample data are provided, severely limiting understanding of the data structure and analytical potential.
• The data is derived from a specific, controlled cell-based assay, which may not directly translate to in vivo disease models or patient heterogeneity.

Provenance

Source

figshare, authored by Lohany Dias Mamede.

Collection Method

Generated from experiments using a quantitative cell-based reporter (human biosensor cell line) to study TDP-43 aggregation and dysfunction.

Freshness

Last updated in March 2026.