TDP-43 Aggregation Reporter Data for Neurodegenerative Disease Study

2026 data from a cell-based reporter study on TDP-43 protein aggregation and dysfunction in neurodegenerative diseases. The dataset, generated by Lohany Dias Mamede, supports analysis of seeding-induced pathological features like cryptic exon splicing and DNA damage. It is a small dataset (12.7 KB) provided in XLSX format.

Use Cases

• Analyze the relationship between TDP-43 aggregate seeding and the activation of cryptic exon splicing in reporter cells.
• Quantify the impact of ataxin-2 level reduction on TDP-43 aggregation and activity restoration metrics.
• Model the feed-forward mechanism of TDP-43 autoregulation disruption using seeding progression data.
• Compare signature features of diminished TDP-43 activity, such as increased DNA damage, between cell lines and human neuron models.

Strengths

• Data is recent, last updated in March 2026.
• Dataset is focused on a specific, quantitative cell-based reporter for TDP-43 pathology.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• Very small dataset size (12.7 KB), indicating limited scope and sample size.
• Column structure and row count are unknown, complicating direct analytical use.
• Data is specific to an experimental cell model, limiting generalizability to in vivo systems.

Provenance

Source

figshare, authored by Lohany Dias Mamede.

Collection Method

Generated from a human biosensor cell line reporter experiment studying TDP-43 aggregation seeding.

Freshness

Last updated 2026-03-24.