TDP-43 Aggregation Reporter Data for Neurodegenerative Disease Research

Figshare dataset by Lohany Dias Mamede, published March 2026, contains experimental data supporting a study on TDP-43 protein aggregation in neurodegenerative diseases. The data, provided in an XLSX file, was used to generate S7C Fig in the associated publication. It originates from a cell-based reporter assay designed to quantify TDP-43 aggregation and functional loss.

Use Cases

• Analyze the correlation between TDP-43 aggregation seeding and increased DNA damage measurements from the reporter assay.
• Model the relationship between aggregate seeding and the activation of cryptic exon splicing events captured in the data.
• Investigate the impact of modulating factors like ataxin-2 levels on TDP-43 nuclear localization and activity metrics.

Strengths

• Data is directly linked to a peer-reviewed scientific publication on TDP-43 pathology.
• Released under a permissive CC BY 4.0 license for broad reuse.
• Focuses on a quantitative cell-based reporter model for a key neurodegenerative disease mechanism.

Limitations

• Very small dataset at only 9.2 KB, indicating limited scope and likely few data points.
• No column names or sample data are provided, obscuring the data's specific structure and variables.
• Data is supplementary to a single figure, offering a narrow view rather than a complete experimental dataset.

Provenance

Source

Lohany Dias Mamede via figshare

Collection Method

Generated from a human biosensor cell line reporter assay measuring TDP-43 aggregation and function.

Freshness

Last updated March 2026.