TDP-43 Aggregation and Dysfunction Reporter Cell Line Data

Experimental data from a human biosensor cell line used to study TDP-43 protein aggregation and its functional consequences in neurodegenerative disease. The dataset supports figures S9A and S9C–S9D from the associated research publication. It is provided in an XLSX file under a CC BY 4.0 license by author Lohany Dias Mamede.

Use Cases

• Analyze the correlation between TDP-43 aggregate seeding and increased DNA damage as a signature feature of dysfunction.
• Model the toxic feed-forward mechanism of TDP-43 autoregulation disruption initiated by aggregate seeding.
• Investigate the impact of reducing ataxin-2 levels on TDP-43 aggregation and activity restoration in the reporter system.
• Study the activation of cryptic exon splicing as a functional readout of diminished TDP-43 activity in human neurons.

Strengths

• Data is directly tied to a specific, peer-reviewed research output, supporting figures S9A and S9C–S9D.
• Focuses on a quantitative cell-based reporter model for TDP-43 pathology, a central mechanism in fatal neurodegenerative disorders.
• Dataset is openly available under a permissive CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 17.2 KB, indicating limited scope and likely containing only summary or illustrative data, not raw high-throughput measurements.
• Specific data structure, column definitions, and row counts are not provided, complicating direct analytical use without consulting the source publication.
• Data is derived from a specific, controlled in vitro cell model, which may not fully capture the complexity of human neurodegenerative disease.

Provenance

Source

figshare, associated with a research publication on TDP-43 pathology.

Collection Method

Generated from experiments using a characterized human biosensor cell line reporter for TDP-43 aggregation and function.

Freshness

Last updated March 24, 2026.