Pediatric Tonsillectomy Clinical Trial Data on Dexmedetomidine Effects

31 pediatric patients were randomized to evaluate inhaled Dexmedetomidine's effects on sedation, pain, and oxidative stress after tonsillectomy. The dataset includes perioperative monitoring of Ramsey sedation scores, Bispectral index, vital signs, and postoperative pain and delirium scores, alongside venous blood samples for redox and inflammatory markers. Authored by Vesna V. Stevanovic and last updated on 2026-05-11, this 22.5 KB Excel file contains results from a prospective randomized clinical pilot study.

Use Cases

• Compare postoperative pain control based on VAS pain scores monitored for 12 hours.
• Analyze the effect of Dexmedetomidine on sedation levels using Ramsey sedation scores and Bispectral index values.
• Investigate oxidative stress by comparing pre- and postoperative levels of malondialdehyde (MDA), nitrogen monoxide, glutathione, and superoxide dismutase activity.
• Evaluate perioperative hemodynamic and respiratory stability using monitored vital signs like heart rate and blood pressure.
• Assess opioid consumption differences between treatment and control groups using recorded fentanyl and alfentanil dosages.

Strengths

• Dataset includes results from a randomized controlled trial with 31 pediatric patients (16 in treatment, 15 in control group).
• Contains detailed perioperative time-series data on sedation, analgesia, and physiological parameters.
• Measures both clinical outcomes (pain, delirium) and laboratory biomarkers (oxidative stress, inflammatory markers).
• Specific statistical results are reported, such as a significant difference in postoperative MDA levels (88.93 ± 1.19 vs. 95.05 ± 1.58).

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small (22.5 KB), indicating limited scope and sample size.
• Data may reflect bias inherent to a single-center pilot study.

Provenance

Source

figshare, author Vesna V. Stevanovic.

Collection Method

Prospective randomized clinical pilot study with venous blood sampling and perioperative monitoring.

Time Range

Study period not specified; data covers perioperative and up to 12 postoperative hours.

Freshness

Last updated 2026-05-11 17:37:50.