Tuberculosis Outcomes in Mexican Patients with Chronic Kidney Disease

Encompassing clinical data from 51 tuberculosis patients in Mexico, comparing outcomes between 17 patients with advanced chronic kidney disease (ACKD) and 34 matched controls. It includes information on patient mortality, cure rates, and treatment regimens over an one-year follow-up period from 2013 to 2024.

Use Cases

• Compare all-cause mortality rates at 1 year between ACKD and non-ACKD patient groups.
• Analyze TB-related mortality and cure rates across different underlying CKD causes like lupus or diabetes.
• Examine the use and outcomes of the local pragmatic alternating treatment regimen received by 68% of CKD patients.
• Perform a sensitivity analysis on mortality outcomes after excluding HIV-positive patients from the cohort.

Strengths

• Data covers a specific, understudied population of TB patients with advanced chronic kidney disease in Latin America.
• Includes a matched control group of 34 non-ACKD patients for comparative analysis.
• Study period spans 11 years from 2013 to 2024, providing longitudinal outcome data.

Limitations

• Very small sample size of 51 total patients limits statistical power and generalizability.
• Low event rates for key outcomes like mortality and relapse prevented multivariate analysis.
• Findings are preliminary and lack pharmacokinetic validation of the treatment regimens used.

Provenance

Source

Observational-analytical study by José Arturo Hernández-Ibarra.

Collection Method

Patients aged ≥18 with microbiologically or histologically confirmed TB were included and compared based on kidney function (GFR).

Time Range

2013 to 2024

Freshness

Data collection concluded in 2024, with the dataset last updated in March 2026.

Geography

Mexico, from a tertiary care center.