Cell-Free Fetal DNA Levels and Pregnancy Outcomes in a Large Cohort

A dataset from a 2026 study investigating the association between first-trimester cell-free fetal DNA concentration and risks of preterm birth and low birth weight. The dataset includes data from a propensity score-matched cohort of 682 preterm birth cases matched with 1,983 controls and 533 low birth weight cases matched with 1,579 controls. It was created by Xiaosa Wang and shared under a CC-BY-4.0 license.

Use Cases

• Predicting preterm birth risk based on first-trimester cell-free fetal DNA levels.
• Analyzing threshold effects for low birth weight risk based on biomarker concentration.
• Training propensity score matching models for observational clinical studies.
• Building hierarchical regression models to adjust for pregnancy-related confounders.
• Conducting subgroup analyses of demographic factors on pregnancy outcomes.

Strengths

• Includes data from a large, propensity score-matched cohort (682 PTB cases matched with 1,983 controls).
• Study design employed multivariate logistic regression and hierarchical models to assess associations.
• Dataset is openly licensed (CC-BY-4.0) for reuse and analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale (341.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Data collected for a clinical study using propensity score matching analysis.

Freshness

Last updated 2026-05-11 17:29:21; freshness should be verified.