Densities of Interconnecting Microvessels in a Diabetic Mouse Model

Data from a study tracking retinal microvascular changes in male Ins2Akita x NG2DSRed mice aged 7–61 weeks, compared to age-matched euglycemic controls. The dataset, authored by Fei Shang and shared on figshare, includes analyses of vessel density, branching, length, tortuosity, pericyte density, and plexus connectivity. It was last updated on 2026-05-28.

Use Cases

• Analyzing the impact of sustained hyperglycemia on retinal vessel density and branching patterns.
• Comparing microvascular metrics like tortuosity and pericyte density between diabetic and control mouse models.
• Investigating the connectivity between vascular plexuses at different eccentricities from the optic disc.
• Correlating in vivo adaptive optics scanning light ophthalmoscope (AOSLO) imaging with ex vivo confocal microscopy data.

Strengths

• Includes data from 27 mice (14 hyperglycemic, 13 euglycemic controls) across an age range of 7–61 weeks.
• Analyzes multiple quantitative vascular metrics: vessel density, branching, length, tortuosity, pericyte density, and plexus connectivity.
• Contains longitudinal imaging data from one hyperglycemic mouse tracked for 12 weeks from 24–36 weeks of age.

Limitations

• Dataset is very small at 5.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Confocal microscopy imaging of retinal flat mounts and adaptive optics scanning light ophthalmoscope (AOSLO) imaging.

Time Range

Mouse ages 7–61 weeks, with longitudinal data from 24–36 weeks.

Freshness

Last updated 2026-05-28 17:30:22; freshness should be verified.