Axon Morphology and Functional Recovery in Rat Sciatic Nerve Injury Model

Lewis rats were used as a model system for isograft transplants to repair segmental-loss sciatic nerve injuries. The dataset likely contains measurements of axonal diameter, g-ratios, and Sciatic Functional Index (SFI) scores for groups treated with or without polyethylene glycol (PEG) fusion and FK506. Cathy Z. Yang published the data on figshare, with a last update recorded as 2026-05-21.

Use Cases

• Compare axonal regeneration outcomes based on treatment with PEG-fusion versus negative control groups.
• Analyze the relationship between axonal diameter, g-ratio, and behavioral recovery as measured by the Sciatic Functional Index (SFI).
• Investigate the effect of localized FK506 treatment on long-term functional recovery after nerve repair.
• Model the impact of graft length (5-mm or 10-mm) on morphological and functional repair success.

Strengths

• Data is derived from a controlled animal model using genetically identical Lewis rats.
• Experimental groups are well-specified, including PEG-fusion and negative control groups with defined gap lengths.
• License is CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• The dataset is very small at 9.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data likely originates from a laboratory study involving surgical repair, morphological analysis, and behavioral scoring in a rat model.

Freshness

Last updated 2026-05-21 17:22:55; freshness should be verified.