Detailed Information of Univariate GWAS for Age-Related Eye Disease

11 genome-wide significant loci were identified for Age-related eye disease (ARED) using Genomic Structural Equation Modeling and post-processing analysis of GWAS. The research by Luqi Gao presents a genetic landscape of ARED by analyzing tissue-, cell layer-, and genomic element-associated gene signals. The dataset is available as a 9.3 KB XLSX file last updated in May 2026.

Use Cases

• Prioritizing candidate SNPs for functional validation based on statistically prioritized independent ARED variants.
• Conducting transcriptome-wide association studies using the identified tissue- and cell layer-associated gene signals.
• Annotating genetic variants in relation to age-related ocular vulnerabilities using the provided functional annotations.

Strengths

• Identifies 11 genome-wide significant loci for Age-related eye disease.
• Applies multiple analysis methods including Genomic-SEM and diverse transcriptome-wide association approaches.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 9.3 KB, indicating limited scope.

Provenance

Source

Luqi Gao via figshare

Collection Method

Genomic Structural Equation Modeling and Post-processing analysis of Genome-Wide Association Studies.

Freshness

Last updated 2026-05-14 17:48:40